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Duy The Phan
Triet Duy Anh Ngo


Paper-based sensor is an innovation technology for fabricating simple, lowcost, portable and disposable analytical device for many application areas including clinical diagnosis, food quality control and environmental monitoring. It reports a simple yet sensitive multilayer sensor based on the colorimetric reaction between polyphenols and Fe3+. The sensor was fabricated by alternative assembly of a chitosan layer, Fe3+ complexes and an alginate sodium layer on filter
paper modified with a TiO2 layer. After five cycles repeated assembly, the obtained sensor achieved good hydrophobicity, and together with the specific affinity of chitosan, polyphenols in aqueous samples can be pre-concentrated on the surface of the sensor, leading to improvement of the sensor sensitivity. The  detection limits for model polyphenols gallic acid was 0.012 ppm with a wide linear range between 0,02 and 6.1 ppm. The colorimetric multilayer sensor was further applied to determine the antioxidant activity of red wine and green tea samples through the polyphenols content analysis. The sensor obtained here can
serve as a cheap and convenient for real-time quality analysis of the antioxidant products.


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How to Cite
Phan, D. and Ngo, T. (2020) “APPLICATION OF CHITOSAN IN PAPER-BASED SENSOR FABRICATION FOR THE DETERMINATION OF ANTIOXIDANT ACTIVITY”, The Scientific Journal of Tra Vinh University, 1(3), pp. 88-95. Available at: (Accessed: 16April2021).


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