SELECTION OF ANIMAL MODEL FOR EXPERIMENTS IN BIOMEDICAL RESEARCH

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Cuong Thi Vu
Quynh Thi Huong Pham

Abstract

Experimental animals are one of the most important tools in biomedical research, biotechnology and food technology. It determines the success or failure, slow or fast temp of a research. In this work, we would like to present some major advantages of the tiny experimental animal, named C.elegans model. C.elegans is a
tiny organism about 1mm in length, transparent body, short life cycle, easy nurturing conditions, small number of genes, whole gene contains only 19,735 protein-coding genes and 1300 protein non-coding RNA genes. C.elegans is the animal, which the genetic map is entirely decoded with 80% similarity of adult human genes. In 1963 Sydney Brenner published the research works on genetics of these experimental animals. Next, there are published numbers of works on C.elegans biological discoveries such as apoptosis, the inhibition of gene expression of RNA molecules (RNAi), the Green Fluorescent Protein (GFP), the activity
regulations of genes, responsible for the aging process, and series of publications relating to life expectancy, prolonged lifespan and inhibition of cancer mechanisms. . . In the previous study, we also selected C.elegans as the experimental animal model, used in the work "Establishing Evaluation Methods for biological effect of Ganoderma on C.elegans," published in the journal "Chinese Journal of Cell Biology" and "The antioxidation and anti-aging effects of Ganoderma  lucidum in Caenorhabditis elegans" are published in "Experimental Gerontology".

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How to Cite
Vu, C. and Pham, Q. (2020) “SELECTION OF ANIMAL MODEL FOR EXPERIMENTS IN BIOMEDICAL RESEARCH”, The Scientific Journal of Tra Vinh University, 1(3), pp. 75-81. Available at: http://journal.tvu.edu.vn/index.php/journal/article/view/228 (Accessed: 16April2021).
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Proceeding

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