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Cuong Thi Vu
Quynh Thi Huong Pham


Experimental animals are one of the most important tools in biomedical research, biotechnology and food technology. It determines the success or failure, slow or fast temp of a research. In this work, we would like to present some major advantages of the tiny experimental animal, named C.elegans model. C.elegans is a
tiny organism about 1mm in length, transparent body, short life cycle, easy nurturing conditions, small number of genes, whole gene contains only 19,735 protein-coding genes and 1300 protein non-coding RNA genes. C.elegans is the animal, which the genetic map is entirely decoded with 80% similarity of adult human genes. In 1963 Sydney Brenner published the research works on genetics of these experimental animals. Next, there are published numbers of works on C.elegans biological discoveries such as apoptosis, the inhibition of gene expression of RNA molecules (RNAi), the Green Fluorescent Protein (GFP), the activity
regulations of genes, responsible for the aging process, and series of publications relating to life expectancy, prolonged lifespan and inhibition of cancer mechanisms. . . In the previous study, we also selected C.elegans as the experimental animal model, used in the work "Establishing Evaluation Methods for biological effect of Ganoderma on C.elegans," published in the journal "Chinese Journal of Cell Biology" and "The antioxidation and anti-aging effects of Ganoderma  lucidum in Caenorhabditis elegans" are published in "Experimental Gerontology".


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Vu, C. and Pham, Q. (2020) “SELECTION OF ANIMAL MODEL FOR EXPERIMENTS IN BIOMEDICAL RESEARCH”, The Scientific Journal of Tra Vinh University, 1(3), pp. 75-81. Available at: (Accessed: 16April2021).


[1] Ann K. Corsi, Bruce Wightman, and Martin Chalfie.,
2015, A Transparent window into biology: A primer
on Caenorhabditis elegans.,
[2] Antikainen, H., Driscoll, M., Haspel, G., Dobrowolski, R., 2017. TOR-mediated regulation of
metabolism in aging. Aging Cell 16 (6), 1219–1233.
[3] Baby S, Johnson AJ, Govindan B. Secondary
metabolites from Ganoderma. Phytochemistry 2015;
114: 66-101.
[4] Brenner, S., 1974 The genetics of Caenorhabditis
elegans. Genetics 77: 71-94. Abstract Article
[5] Brenner, S., 1988 Foreword. The Nematode
Caenorhabditis elegans, edited by W. B. Wood,
Cold Spring Harbor Laboratory Press, Cold Spring
Harbor, NY.
[6] Brenner, S., 1988 Foreword. The Nematode
Caenorhabditis elegans, edited by W. B. Wood,
Cold Spring Harbor Laboratory Press, Cold Spring
Harbor, NY.
[7] Brenner, S., 2002 The worm’s turn. Curr. Biol. 12:
R713. Abstract Article
[8] Burkewitz, K., Weir, H.J., Mair, W.B., 2016. AMPK
as a pro-longevity target. EXS 107, 227–256.
[9] Castel, S.E., Martienssen, R.A., 2013. RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond. Nat. Rev. Genet.
14 (2), 100–112.
[10] Chen D, Li PW, Goldstein BA, Cai W, Thomas EL,
Chen F, et al. Germline signaling mediates the synergistically prolonged longevity produced by double
mutations in daf-2 and rsks-1 in C. elegans. Cell Rep
2013; 5(6): 1600-10.
[11] Hengartner, M.O., Horvitz, H.R., 1994. C.elegans
cell survival gene ced-9 encodes a
[12] Kennedy, M. W., 2013 Ascaris – Antigens, allergens, immunogenetics, protein structures, pp. 51-79
in Ascaris, The Neglected Parasite, Ed. 100, Chap. 3.
Elsevier, Holland.
[13] Kenyon, C.The first long-lived mutants: Discovery of
the insulin/IGF-1 pathway for ageing. Philos Trans R
Soc Lond B Biol Sci 2011; 366(1561): 9-16.
[14] Kohda H, Tokumoto W, Sakamoto K, Fuj II M,
Hirai Y, Yamasaki K, et al. The biologically active
constituents of Ganoderma Lucidum (Fr.) Karst. Histamine release-inhibitory triterpenes. Chem Pharm
Bull (Tokyo), 1985. 33(4): p. 1367-74.
[15] Kumar, S., Lombard, D.B., 2016. Finding Ponce de
Leon’s pill: challenges in screening for anti-aging
molecules. F1000Res. 5.
[16] Li J, Ebata A, Dong Y, Rizki G, Iwata T, Lee SS.
Caenorhabditis elegans HCF-1 functions in longevity
maintenance as a DAF-16 regulator. PLoS Biol 2008;
6(9): e233.
[17] Petrascheck, M., Ye, X., Buck, L.B., 2007. An antidepressant that extends lifespan in adult Caenorhabditis
elegans. Nature 450 (7169), 553–556.
[18] Sulston, J. E., E. Schierenberg, J. G. White, and J.
N. Thomson, 1983 The embryonic cell lineage of
the nematode Caenorhabditis elegans. Dev. Biol. 100:
[19] Thompson, O., M. Edgley, P. Strasbourger, S. Flibotte, B. Ewing et al., 2013 The million mutation
project: a new approach to genetics in Caenorhabditis
elegans. Genome Res. 23: 1749-1762.
[20] Liu Bo, Gao Yu. Progress of Ganoderma Lucidum
polysaccharides in pharmacology. Journal of Qiqihar
University of Medicine 2013; 34(11): 1672-4.